CLARIOstar® Plus Multi-mode Microplate Reader with Advanced LVF Monochromators™
CLARIOstar® Plus Multi-mode Microplate Reader with Advanced LVF Monochromators™
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The CLARIOstar® Plus is BMG LABTECH’s most flexible multi-mode plate reader. It comes equipped with their patented LVF Monochromators™, filters, and spectrometer. Flexibility combined with the best sensitivity of its class and their newly developed Enhanced Dynamic Range technology makes it the ideal reader for assay development.
- Innovative monochromators for increased sensitivity
- Fully flexible wavelengths and bandwidths
- Spectral scanning in absorbance, fluorescence intensity, and luminescence
- Largest dynamic range with no manual intervention
- Rapid full-plate autofocus
- Dedicated features for live cell-based assays
- Ultra-fast data sampling (100 measurements/second)
- Dedicated laser for Alpha Technology
- Easily integrated into automated systems
Availability:On Request
SKU
IBMG430-501
BrandBMG LABTECH
The CLARIOstar® Plus is a high-performance multi-mode microplate reader that fits the current and future needs of your laboratory, whether in academia, a core facility, biotech or pharma. This multi-mode reader combines the flexibility of advanced LVF Monochromators™ with highly sensitive filters and an ultra-fast UV/vis spectrometer. It includes features like Enhanced Dynamic Range (EDR) and automatic focus technologies that make manual settings superfluous and detection optimisation easier than ever to help simplify your workflow in the lab. The instrument is upgradable and can be equipped with all the leading non-isotopic detection technologies.
Atmospheric Control Unit, temperature incubation, multiple shaking, well scan and reagent injectors make the CLARIOstar® Plus the ideal platform for any live cell-based assay.
The CLARIOstar® Plus now comes with Voyager, BMG LABTECH’s new microplate reader control interface. Designed to remove complexity while maximising flexibility, Voyager makes data acquisition more intuitive than ever.
| Detection Modes | Fluorescence intensity (incl. FRET) Fluorescence polarization AlphaScreen®/AlphaLISA®/AlphaPlex™ Luminescence (flash and glow) - incl. BRET Time-resolved fluorescence TR-FRET UV/vis absorbance spectra |
| Measurement Modes | Top and bottom reading Endpoint and kinetic Sequential multi-excitation Sequential multi-emission Spectral scanning (fluorescence, luminescence, absorbance) Ratiometric measurements Well scanning |
| Microplate Formats | 6- to 1536-well plates, user-definable LVis Plate with 16 low volume microspots (2 μL) |
| Microplate Carrier | Robot compatible |
| Light Sources | High energy xenon flash lamp Dedicated laser for AlphaScreen®/AlphaLISA®/AlphaPlex™ |
| Detectors | Low-noise photomultiplier tube Red-shifted photomultiplier tube CCD spectrometer |
| Wavelength Selection | Dual Linear Variable Filter (LVF) Monochromators™ Linear Variable Dichroic Mirror Separates ex and em LVF Monochromators Optical filters: Ex and em slides hold 4 filters each LVF Monochromators + optical filters Use one for ex and the other for em UV/Vis absorbance spectrometer: Full spectra or 8 distinct wavelengths in < 1 sec/well |
| Spectral Range | Filters FI, FP, TRF: 240 - 740 nm or 240 - 900 nm (red-shifted PMT) LUM: 240 - 740 nm LVF Monochromators™ FI: 320 - 740 nm or 320 - 840 nm (red-shifted PMT) LUM: 320 - 740 nm Linear Variable Dichroic 340 - 740 nm or 340 - 760 nm (red-shifted PMT) Spectrometer ABS: 220 - 1000 nm; wavelength precision: ≤ 0.5 nm |
| Sensitivity | FI filters (top) < 0.15 pM (< 3 amol/well FITC, 384sv, 20 μL). FI filters (bottom) < 1.0 pM (< 50 amol/well FITC, 384g, 50 μL). FI monochromator (top) < 0.35 pM (< 7 amol/well FITC, 384sv, 20 μL). FI monochromator (bottom) < 3.0 pM (< 150 amol/well FITC, 384g, 50 μL). Dynamic Range: 8 decades in a single measurement. FP < 0.5 mP SD at 1 nM FITC (384sv, 20 μL). HTRF® (black and white microplates) Reader Control Kit (Eu) after 18h (384sv, 20 μL). Delta F > 880% (High Calibrator). Delta F > 30% (Low Calibrator). TRF < 20 fM europium, 384, 80 μL (<1.6 amol/well). LUM < 0.4 pM (< 8 amol/well ATP, 384sv, 20 μL). Dynamic range: 8 decades in a single measurement. AlphaScreen® with laser. < 5 pM (< 100 amol/well P-Tyr-100, 384sv, 20 μL). ABS with spectrometer. Selectable spectral resolution: 1, 2, 5, and 10 nm. OD range: 0 to 4 OD; photometric resolution: 0.001 OD. Accuracy: < 1% at 2 OD. Precision: < 0.5% at 1 OD and < 0.8% at 2 OD. Linearity: ≤ 0.8% at 2.0 OD. |
| Read Times | Flying mode (1 flash) 8 s (96), 15 s (384), 28 s (1536) 10 flashes 19 s (96), 57 s (384), 3 min 4 s (1536) |
| Shaking | Linear, orbital, and double-orbital with user-definable time and speed |
| Incubation | +3 °C above ambient up to 45 °C or 65 °C The upper heating plate of the incubation chamber operates at 0.5 °C more than the lower plate. This prevents condensation build-up on the lid or sealer |
| Software | Multi-user reader control (SMART Control and Voyager) and data analysis software (MARS). Voyager is compatible with CLARIOstar Plus readers from serial number 430-4001. FDA 21 CFR Part 11 compliance available with SMART Control and MARS. Integrated fluorophore library. |
| Dimensions | Width: 45 cm, depth: 51 cm, height: 40 cm; weight: 32 kg |
| Optical Filters | Excitation and emission slides for 4 filters each |
| Optical Path Guides | Top and bottom: free-air optical light path guided by motor-driven mirrors and dichroics |
| Z-Adjustment | Automatic focal height adjustment (0.1 mm resolution) |
| Reagent Injection | Up to 2 built-in reagent injectors Individual injection volumes for each well: 3 to 500 µL (optionally up to 2 mL) Variable injection speed up to 420 µL/s Reagent back flushing |
| Integrated Barcode Reader | Up to two integrated barcode readers |
| Power Requirements | 100 or 115 or 230 V, 50/60 Hz, auto ranging |
| Power Consumption | Normal operating conditions: 50 W Idle State: 20W Switched off: 0W max. 300 VA |
Optional Accessories
| LVis Plate | Sample capacity: sixteen separate microdrop wells for 2 µL samples; one standard cuvette position for up to 1 mL samples Quality Control Internal Standards (optional): four NIST traceable optical density filters (approximate values of 0.1, 0.3, 0.6 and 1.0 OD); one holmium oxide filter for wavelength accuracy Dimensions: conforms to SBS standards for microplates |
| THERMOstar | Microplate incubator and shaker |
| Atmospheric Control Unit (ACU) | Actively regulates O2 and CO2 - 0.1-20% |
| Stacker | Magazines for up to 50 plates - continuous loading feature. Only compatible with SMART Control. |
| Optical Filters | Excitation and emission filters |
| Upgrades | The CLARIOstar Plus can include all or any combination of features listed below at purchase. Upgrading with additional features is possible at any time. Please contact your local representative for more details or a quote |
| * | LOD = 3 x SD (20 blanks) / slope (6 pt std curve) AlphaScreen® P-Tyr-100 assay kit, PerkinElmer, #6760620C Microplates: white for LUM, AlphaScreen®, TRF; black for FI, FP; clear for ABS 96 = 96-well microplates 384sv = 384-well small volume microplates 384g = 384-well glass bottom microplates 1536 = 1536-well microplates |
| Brand | BMG LABTECH |
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