chemagic™ Prime™ Instrument
chemagic™ Prime™ Instrument
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- Fully automated DNA/RNA extraction, normalisation, and PCR setup in one walk-away system.
- High-throughput capacity: Processes 1–192 samples per run; handles sample volumes from 50 µL to 10 mL.
- Patented M-PVA Magnetic Bead Technology for high yields and purity, proven for NGS, PCR, MLPA, and long-read sequencing.
- Flexible sample compatibility: Blood, saliva, plasma, swabs, wastewater, and more.
- Integrated barcode scanning and LIMS-compatible tracking for traceability and compliance.
- User-friendly touchscreen interface with intuitive software and fast setup.
- On-deck heating, cooling, shaking, and UV disinfection for workflow optimisation and safety.
- Compact design for high-throughput labs requiring reliable, automated nucleic acid purification.
For research use only. Not for use in diagnostic procedures.
Availability:On Request
SKU
IREVCHEMPRIME
BrandRevvity
Fully Automated DNA and RNA Isolation, Normalisation, and PCR Setup for Research Workflows
Overview
The chemagic™ Prime™ Instrument is a next-generation, fully automated system for DNA and RNA purification, designed to streamline complex laboratory workflows by integrating:
- Primary sample transfer
- DNA/RNA extraction using M-PVA Magnetic Bead Technology
- Optional normalization
- PCR setup
into a single, walk-away platform. Featuring 8 pipetting channels and advanced liquid handling capabilities, the system delivers high-purity, contaminant-free nucleic acids in high concentrations, ensuring robust support for downstream applications including NGS, PCR, MLPA, and long-read sequencing.
Technical Specifications
- Dimensions: 0.865 m (W) × 2.285 m (D) × 1.94 m (H)
- Sample Throughput: 1–192 samples per run
- Sample Volume: 50 µL – 10 mL
- Applications: cfDNA, DNA, RNA, Viral Nucleic Acids
- User Interface: Touchscreen with intuitive software
- Traceability: Integrated barcode scanner, LIMS-compatible
Key Benefits
End-to-End Workflow Automation
Handles all steps from sample transfer to PCR setup, reducing manual intervention and minimising human error.
Validated, Single-Supplier Solution
Combines extraction kits and instrumentation from Revvity for a streamlined, consistent workflow with high reproducibility.
Compact High-Throughput Capability
Processes up to 192 samples per run with sample volumes up to 10 mL, making it ideal for blood donor screening, pathogen surveillance, and genetic studies.
Patented M-PVA Magnetic Bead Technology
Delivers high yields, integrity, and purity of nucleic acids across diverse sample types.
Applications
- cfDNA and Viral Nucleic Acid Extraction
- DNA/RNA Isolation from blood, saliva, plasma, swabs, and wastewater
- High-resolution SNP genotyping
- Pathogen surveillance (e.g., SARS-CoV-2, HIV, HBV, HCV, malaria)
- Biobanking and population studies
Key Features
Performance
- Delivers ultra-pure nucleic acids suitable for NGS, PCR, MLPA, and long-read sequencing.
- Ensures high sensitivity and traceability in high-throughput screening, as demonstrated in blood donor screening (up to 552 blood bags/day).
Flexibility
- Processes 1–192 samples/run across a range of sample volumes (50 µL – 10 mL).
- Supports diverse tube formats and sample types in a single run.
- Enables on-deck normalisation, assay setup, and eluate transfer.
Automated Traceability
- Integrated 1D/2D barcode scanning.
- LIMS-compatible log files and customizable run reports.
- Full reagent and tip tracking for 100% traceability.
Efficiency
- Cost-effective buffer dispensing without expensive cartridges.
- Supports multiple kits with a switch box for seamless workflow transitions.
- On-deck heating, cooling, and shaking options for optimised protocols.
User-Friendly Operation
- Fast startup with intuitive software and guided setup.
- LED status lights and email notifications for error reporting.
- UV disinfection and drop cover for enhanced safety and contamination prevention.
Configurations and Processing Options
The chemagic™ Prime™ Instrument can be configured with two chemagic Rod Heads for flexibility in throughput and sample volume:
| Rod Head | Sample Capacity | Sample Capacity | Sample Capacity |
|---|---|---|---|
| chemagic 24 Rod Head | 1–48 | 200 µL – 10 mL | ~75 min for 4 mL blood |
| chemagic 96 Rod Head | 1–192 | 50 µL – 1.5 mL | ~55 min for 400 µL blood |
Exemplary Workflows
- High-Throughput Blood Donor Screening: Traceable detection of HIV, HBV, HCV, and malaria with high sensitivity.1
- Autism Genetic Studies: High-quality DNA extraction from saliva for high-resolution SNP genotyping.2
- Pathogen Surveillance: Sensitive detection of SARS-CoV-2 in blood, swabs, and wastewater for public health monitoring.3-6
chemagic™ Prime Kits
Dedicated kits for DNA and RNA extraction from blood, saliva, plasma, and other sample matrices are available, featuring:
- Ready-to-use reagents
- Included plastic consumables
- Patented chemagic™ M-PVA Magnetic Bead Technology for reliable results
Supporting Literature
- Costa E, Rocha D, Lopes JIF, et al. Detection of Plasmodium spp. in asymptomatic blood donors by the new Brazilian NAT PLUS HIV/HBV/HCV/Malaria Bio-Manguinhos kit. Transfusion. 2024;64(3):501-509. doi:10.1111/trf.17726
- Bui DT, Ton ANV, Nguyen CTD, et al. Pathogenic/likely pathogenic mutations identified in Vietnamese children diagnosed with autism spectrum disorder using high-resolution SNP genotyping platform. Sci Rep. 2024;14(1):2360. Published 2024 Jan 29. doi:10.1038/s41598-024-52777-y
- Döhla M, Schulte B, Wilbring G, et al. SARS-CoV-2 in Environmental Samples of Quarantined Households. Viruses. 2022;14(5):1075. Published 2022 May 17. doi:10.3390/v14051075
- Lou EG, Sapoval N, McCall C, et al. Direct comparison of RT-ddPCR and targeted amplicon sequencing for SARS-CoV-2 mutation monitoring in wastewater. Sci Total Environ. 2022;833:155059. doi:10.1016/j.scitotenv.2022.155059
- Streeck H, Schulte B, Kümmerer BM, et al. Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany. Nat Commun. 2020;11(1):5829. Published 2020 Nov 17. doi:10.1038/s41467-020-19509-y
- LaTurner ZW, Zong DM, Kalvapalle P, et al. Evaluating recovery, cost, and throughput of different concentration methods for SARS-CoV-2 wastewater-based epidemiology. Water Res. 2021;197:117043. doi:10.1016/j.watres.2021.117043
Frequently Asked Questions (FAQs): chemagic™ Prime™ Instrument
Q: What is the chemagic™ Prime™ Instrument used for?
A: It is a fully automated system for DNA and RNA extraction, optional normalisation, and PCR setup in a single walk-away platform for high-throughput research workflows.
Q: How many samples can the chemagic™ Prime™ process per run?
A: It can process 1 to 192 samples per run, making it suitable for high-throughput labs.
Q: What sample volumes can it handle?
A: It can process sample volumes from 50 µL to 10 mL, offering flexibility across different sample types.
Q: What types of samples can the chemagic™ Prime™ process?
A: It can process blood, saliva, plasma, swabs, wastewater, and other biological samples for DNA/RNA extraction.
Q: Is this instrument suitable for diagnostic procedures?
A: No, the chemagic™ Prime™ Instrument is for research use only and is not intended for diagnostic procedures.
Q: What technology does the chemagic™ Prime™ Instrument use?
A: It uses Revvity’s patented M-PVA Magnetic Bead Technology, providing high yields, purity, and integrity of nucleic acids.
Q: What are the dimensions of the chemagic™ Prime™ Instrument?
A: It measures 0.865 m (W) × 2.285 m (D) × 1.94 m (H).
Q: What applications are supported by the chemagic™ Prime™?
A: Applications include cfDNA and viral nucleic acid extraction, DNA/RNA isolation from various sample types, NGS, PCR, MLPA, long-read sequencing, high-resolution SNP genotyping, pathogen surveillance, biobanking, and population studies.
Q: How does the instrument support workflow efficiency?
A: It automates the full workflow from sample transfer to PCR setup, reducing manual interventions, supporting on-deck heating, cooling, shaking, UV disinfection, and using intuitive touchscreen software for easy setup.
Q: Does the chemagic™ Prime™ support LIMS integration and traceability?
A: Yes, it includes integrated 1D/2D barcode scanning, LIMS-compatible log files, customizable reports, and full reagent and tip tracking for complete traceability.
Q: How does the chemagic™ Prime™ contribute to high-throughput research?
A: It enables fast, reliable nucleic acid extraction and PCR setup for high-volume labs, supporting pathogen surveillance, genetic studies, and blood donor screening with high sensitivity and reproducibility.
Q: What user-friendly features are included with the instrument?
A: It offers an intuitive touchscreen interface, LED status lights, email notifications for errors, and a guided setup for fast startup and operation.
Q: What kits are available for use with the chemagic™ Prime™ Instrument?
A: Dedicated chemagic™ Prime kits are available for DNA and RNA extraction from blood, saliva, plasma, and other sample types, featuring ready-to-use reagents and included consumables.
Q: What are the processing configurations available for the chemagic™ Prime™ Instrument?
A: It offers interchangeable rod heads:
- chemagic 24 Rod Head: 1–48 samples, 200 µL – 10 mL, ~75 min for 4 mL blood.
- chemagic 96 Rod Head: 1–192 samples, 50 µL – 1.5 mL, ~55 min for 400 µL blood.
| Brand | Revvity |
|---|
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