Capitainer®B10 Vanadate Volumetric Dried Blood Spot Card
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- Sample type: Whole blood (finger blood)
- Sample volume: 2 × 10 µl per card
- Target analyte: Phosphatidylethanol (PEth), alcohol biomarker
- Active additive: Sodium metavanadate (NaVO3), integrated PLD inhibitor
- Reproducibility: Better than 0.5 µl SD; CV < 5%
- Outlier rate: < 0.1% (> 3 SD deviation)
- Non-sampling rate: < 5%
- HCT range: 25–55%
- Operating temperature: +15°C to +35°C
- Operating relative humidity: 15–90%
- Use window: Within 30 minutes of opening package
- Card material: Ahlstrom grade 222; > 80% paper; < 1.2 g plastics per device
- Product dimensions: 78 × 43 × 3 mm
- Sample storage: Ambient temperature; freezer storage extends stability
- Regulatory status: CE-IVD (IVDR), EU 2017/746 — EU market only; Research Use Only elsewhere
- Pack size: 50 pcs box
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Optional accessories are available for purchase separately. If your order needs a customised configuration, our technical specialists will follow up with full details before your order is finalised. Contact us via the enquiry form or sales@lasec.com.
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DISCLAIMER: All product images are for illustrative purposes only. Actual products may vary slightly in colours, controls, and visible features.
Availability:On Request
SKU
DCAP210-0052
BrandCapitainer
Product Overview
Volumetric finger-blood collection with integrated PLD inhibitor for PEth testing
The Capitainer®B10Vanadate is a volumetric dried blood spot (DBS) card developed for accurate Phosphatidylethanol (PEth) testing. The card incorporates Capitainer's proprietary technology for integrating the phospholipase D (PLD) inhibitor sodium metavanadate (NaVO3) directly into the paper disc, stopping post-sampling PEth formation at the point of collection.
The card enables PEth testing via finger blood at ambient shipping conditions, without a requirement for phlebotomy or controlled-temperature transport.
- Sample volume: 2 × 10 µl finger blood, volumetric
- Reproducibility: Better than 0.5 µl SDCV < 5%
Key Features
- Accurate: Enables accurate PEth testing from finger blood
- Reliable: Volumetric collection addresses variable spotting in traditional DBS
- Convenient: Finger blood sampling without phlebotomy
- Protected sample: Integrated NaVO3 inhibitor stops post-sampling PEth formation
- User-friendly: Ambient-temperature shipping and storage of collected sample
About PEth and its measurement
What is PEth?
Phosphatidylethanol (PEth) is a direct biomarker for alcohol consumption, produced only in the presence of ethanol through a transphosphatidylation reaction of phospholipase D (PLD). It accumulates in red blood cells with a half-life of approximately 4 days, making it a marker for sustained or repeated alcohol use. Unlike indirect markers such as GGT (Gamma glutamyl transpeptidase), PEth is not elevated by conditions unrelated to ethanol exposure.
The post-sampling formation problem
When blood containing ethanol is collected for PEth analysis, PEth can continue to form after sampling, potentially producing falsely elevated concentrations. In venous blood, storage temperature and shipping conditions must be controlled to limit in vitro PEth formation. The Capitainer®B10Vanadate addresses this by incorporating sodium metavanadate (NaVO3), an effective PLD inhibitor, directly into the paper disc, arresting the formation reaction at the point of collection.
Supporting publication
The performance of the Capitainer® B Vanadate for PEth testing is documented in peer-reviewed literature. See the References section for full citation details.
Application Areas
- Alcohol biomarker testing using PEth as a direct alcohol exposure indicator
- Remote and at-home blood collection for PEth analysis without phlebotomy
- Programmes requiring ambient-temperature postal return of dried blood samples for PEth quantification
Laboratory Use Notes
The Capitainer®B10Vanadate is validated for PEth testing. End-users and laboratories are responsible for validating assay results from Capitainer products for their specific applications.
Stability of individual analytes in DBS samples should be validated by the responsible laboratory. In general, stability increases with lower temperature and lower humidity. Collected sample discs may be stored in a freezer to extend stability. As a general guide, Capitainer references the existing literature on traditional DBS sample stability for individual analytes.
Blood-stained materials and sharps: handle and dispose of according to local regulations for biological waste and sharps.
Regulatory Status
- EU classification: CE-IVD (IVDR), registered under Regulation (EU) 2017/746
- Current market availability: Available within the EU only under IVD registration
- Other markets: Available as Research Use Only (RUO); availability subject to enquiry
- Assay validation responsibility: End-users and laboratories are responsible for validating assay results from Capitainer products
References
- Beck O, Mellring M, Löwbeer C et al. Measurement of the alcohol biomarker phosphatidylethanol (PEth) in dried blood spots and venous blood—importance of inhibition of post-sampling formation from ethanol. Anal Bioanal Chem413, 5601–5606 (2021). https://doi.org/10.1007/s00216-021-03211-z
- Schröck A, Henzi A, Bütikofer P, König S, Weinmann W. Determination of the formation rate of phosphatidylethanol by phospholipase D (PLD) in blood and test of two selective PLD inhibitors. Alcohol. 2018 Dec;73:1–7. https://doi.org/10.1016/j.alcohol.2018.03.003
| Technical Data | |
|---|---|
| Sample type | Whole blood (finger blood) |
| Sample volume | 2 × 10 µl |
| Product dimensions | 78 × 43 × 3 mm |
| Paper material | Ahlstrom grade 222 |
| Paper content | > 80% of device is paper-based |
| Plastics content | < 1.2 g per device |
| Active additive | Sodium metavanadate (NaVO3) — integrated PLD inhibitor |
| Performance | |
| Reproducibility | Better than 0.5 µl as one standard deviation (SD); CV < 5% |
| Outlier rate | Rate of over- or under-sampling (> 3 SD deviation) < 0.1% |
| Non-sampling rate | < 5% |
| Operating Conditions (During Use) | |
| Operating temperature | +15°C to +35°C |
| Relative humidity | 15% to 90% |
| Haematocrit range | 25% to 55% |
| Use window after opening | Must be used within 30 minutes of opening the package |
| Collected Sample Storage | |
| Ambient storage | Collected samples may be stored at room temperature |
| Extended stability | Sample discs may be stored in the freezer to extend analyte stability |
| Analyte-specific stability | Must be validated by the responsible laboratory; refer to DBS literature for guidance |
| Compliance | |
| EU classification | CE-IVD (IVDR), Regulation (EU) 2017/746 |
| Current market | EU only (IVD); other markets as RUO |
| South Africa | Not stated — defaults to RUO; to be confirmed before publishing for any diagnostic use |
| Manufacturer | |
| Manufacturer | Capitainer AB |
| Address | Solna Torg 19, SE-171 45 Solna, Sweden |
Frequently Asked Questions about the Capitainer®B10Vanadate
Q: What is the Capitainer®B10Vanadate used for?
A: It is a volumetric dried blood spot card developed specifically for Phosphatidylethanol (PEth) testing. It collects and stores 2 × 10 µl of finger blood, with an integrated inhibitor that stops post-sampling PEth formation.
Q: Why does PEth testing require an inhibitor in the collection device?
A: When blood containing ethanol is collected, PEth can continue to form after sampling through phospholipase D (PLD) activity. This can produce falsely elevated PEth concentrations. Sodium metavanadate (NaVO3), integrated into the card’s paper disc, inhibits PLD and stops post-sampling PEth formation at the point of collection.
Q: Does phlebotomy equipment need to be available at the sampling site?
A: No. The card is designed for use with finger blood, which can be obtained with a standard lancet without venepuncture or centrifuge equipment.
Q: How should collected samples be stored and transported?
A: Collected samples can be stored and shipped at ambient temperature. For extended storage, the sample disc may be stored frozen. The stability of specific analytes in DBS format should be validated by the responsible laboratory.
| Brand | Capitainer |
|---|
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