It is well known that freeze drying is not only used for water-based (aqueous) samples. Typical applications also include HPLC fractions with organic and inorganic solvents, such as acetonitrile, TFA and other alcohols or products containing t-butanol or DMSO.
How can Martin Christ’s Alpha 3-4 LSCbasic freeze dryer meet the requirements of these challenging solvents?
Some of the challenging organic solvents can potentially be flammable. With additional safety as a consideration, the standard Pirani sensor has been replaced with a capacitive vacuum measurement probe.
Solvents mentioned above can be aggressive therefore only materials with excellent chemical resistance have been used in the design of the instrument, such as stainless-steel condenser, manifold and hose with EPDM seals and mineral glass product chamber.
- High Performance
Solvents with such low freezing points can limit the performance of standard condensers. To counteract this challenge, the Alpha 3-4 LSCbasic is supplied with an internal condenser using a natural refrigerant that reaches -105 °C which is low enough to freeze or liquify most solvents.
- Robust pump
Again, related to harshness of the solvents for these challenging applications, a specialised hybrid pump that offers outstanding chemical resistance is included in the configuration.
An integrated aeration valve allows the drying chamber to be flooded with an inert gas, such as nitrogen, instead of ambient air.
If you are working with organic solvents - the Martin Christ Alpha 3-4 LSCbasic is the ideal solution for your lab.
To find out more, come talk to the Martin Christ specialist on the Lasec stand at analytica Lab Africa.
- Barbara-lee Nel, Product Manager - Instruments